Do you often complain of joint pain accompanied by swollen joints? It could be that it is caused by high uric acid levels. Uric acid is the end result of purine metabolism in the body in the form of crystals. In the body, purine can be generated by all foods, such as from vegetables, nuts, meat, or offal. Under normal circumstances, levels of uric acid in the body should not be exaggerated, but if purine levels too high, then this will be excreted through the urine.
Physiologically in the body there are about 85% of purine compounds, so that the human body requires only about 15% of purines from outside the body.
About gout arthritis
In the case of gouty arthritis, symptoms that often happens is an acute attack that attacks only one joint, accompanied by swelling, redness in the joints, pain, disturbance to move suddenly, which can occur in less than 24 hours. In the case of gouty arthritis, symptoms that often happens is an acute attack that attacks only one joint, accompanied by swelling, redness in the joints, pain, disturbance to move suddenly, which can occur in less than 24 hours.
According to the disease course stages of gout, acute attacks of gout may disappear without treatment within 5-7 days. After the first attack, the patient will be in a situation without complaint, generally last about 1-2 years. This phase, in medical terms is known as inter-critical gout. The disease then goes into the stage of intermittent acute gout arthritis, a condition in which interval of the attack that occurred more frequently and lasted longer, and the number of joints affected more and more.
The final stage is chronic gout arthritis with tofus, which is the disease has lasted more than 10 years old and already there are bumps around the joints, called tofus. In this area (tofus) contained deposits of monosodium uric crystals that cause damage to the joints and surrounding bone. The influence of foods high in purines on gout. Based on a recent study published by Medscape, purine intake from foods high in purines, especially foods of animal origin will increase the risk of gout attacks to 5 times in patients with gout.
The study was conducted by Yuqing Zhang, MD, DSc from the Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University, Massachusetts.This study was followed by the 633 respondents with gout and conducted follow-up for 1 year. Then, respondents reported about the state of gout, and gout attacks ever experienced during the last 12 months. Age of respondents at least 18 years old and living in the United States, and they have to report the data from the medical record.
Then, the respondents are given a few questions about gout attacks ever experienced and their food intake for 2 days before the attack, and for two days when they were not under attack. In this study it was found that the intake of foods high in purines from animal sources has a major contribution to the attacks of gout.
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However, this study still has some shortcomings, because respondents have to recall the data of food intake, amount of food they eat. This led to the recall-refractive. In addition, the bioavailability of foods consumed by each person is different depending on the preparation of foods. Other risk factors are also influence such as sex, alcohol habits, consumption of diuretic drugs, allopurinol, anti-inflammatory (NSAID), and colchicine.
Conclusions on foods high in purines and gout
The conclusion to be drawn from this study is the risk of gout attacks can be reduced by decreasing purine contained in animal sources. Foods high in purines such as offal, shellfish, meat extract, or beef.